PRP has been proposed for several uses in form of after-treatment for various surgical procedures. The main reason for employment PRP preparation the promising regeneration capacities after the most invasive procedures as well as enhancement of results. The growth factors in PRP might accelerate epithelial wound healing, decrease tissue inflammation after surgery, improve the regeneration of bone and soft tissues, and promote tissue vascularization.

The ease with which these preparations are used might be helpful in many surgical procedures. The clinical use of platelet-rich plasma has been proposed as a way of obtaining high concentrations of growth factors involved in tissue healing and regeneration after the invasive surgical performance. It is used to promote the process of tissue repair, improving the quality of healing and healing time. The growth factors present in PRP are capable of forming a fibrin clot, promoting fibroblast proliferation and up-regulating collagen synthesis in the extracellular matrix.

In the case of surgical reconstruction of the anterior cruciate ligament, we can intraoperatively inject the PRP into the graft to accelerate and improve the healing process. In bones regeneration, it improves the process of natural healing by stimulating the capacity of bones restoration, as well as inheriting regenerating capacity while the of lack the ability to spontaneously heal appears.

Independently,  fat transplantation seem to have a role in regenerative medicine; however, the addition of PRP to fat transplants may synergistically enhance graft survival by a number of mechanisms.

improve and accelerates tissue or bone healing

maintaining contour restoration

improves the maintenance and function of fat graft

Autologous fat grafting is used extensively in reconstructive and aesthetic plastic surgery for the correction of soft-tissue volume defects.

REFERENCES:

1. “A Systematic Review of Autologous Platelet-Rich Plasma and Fat Graft Preparation Methods”; US National Library of Medicine National Institutes of Health;  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889438/
2. “Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy”; US National Library of Medicine National Institutes of Health;  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094865/
3. “Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration”; US National Library of Medicine National Institutes of Health; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671651/